Control and regulation of pathways via negative feedback

Control and regulation of pathways via negative feedback.

The biochemical networks found in living organisms include a huge variety of control mechanisms at multiple levels of organization. While the mechanistic and molecular details of many of these control mechanisms are understood, their exact role in driving cellular behaviour is not. For example, yeast glycolysis has been studied for almost 80 years but it is only recently that we have come to un...

Correction to 'Control and regulation of pathways via negative feedback'.

Negative Feedback Regulation of the Tumor

Negative Feedback Regulation of T Cells via Interleukin-2 and FOXP3 Reciprocity

As interleukin-2 (IL2) is central to the clonal expansion of antigen-selected T cells, we investigated the relationship between IL2 and the negative regulatory transcription factor FOXP3. We found IL2 to be responsible for T cell antigen receptor (TCR)-activated FOXP3 expression by both CD4+ and CD8+ human T cells, and as anticipated, FOXP3 expression restricted TCR-stimulated IL2 expression. H...

Introduction to Negative Feedback and Control Systems

1 . Introduction Let us consider the common generic problem of causing a network to produce a given desired output signal. A typical block diagram is illustrated in Fig. 1. We are able to select the input vin(s) arbitrarily, and it is desired to produce a certain specified output vout(s). The problem is that there is an unwanted disturbance vd(s) which also affects the output. We have no contro...